Hey Neil, found this topic helpful for my first acrylic cuts First Acrylic cut - Advice please, am using down cut single flute bit, trochoidal when holes/pockets/contour are wide enough. Down cut isn’t pulling through material as quickly as upcut, discovered my core needed tightening too, so I slow down Z mm/s a bit and over cut hole depth more than usual. Hope that helps, am still new to cutting acrylic, but happy with how cuts are turning out (getting chips not molten plastic around the bit) for my enclosures and MP3DP V4, have only cut 1/8" thick, so no experience with 1/4" thick material.
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