Skr pro wont talk to the pc

I have a 4 axis cnc, it has tft35 lcd with skr pro v1.2. I am having problems with pc seeing my boards usb. I have a few questions, when I configure marlin for my serial ports, . Are the serial ports in the tft 35 effected, or does the lcd take care of that area? I am a little bit confused on how to configure the serial ports in marlin. And I need help with the jumpers. for the serial ports.
The sd card reader slot, and the 2 usb ports, 2 different types of usb. please guys and ladies. Everything else works, the probe, the endstops, Just this is the problem. I don’t know if the tft325 usb port is interfering with the skr pro ports or not. thanks