It also depends on how you want to work with your machine, and what you want to do.
If you did art pieces for money, made from say driftwood and would like to place some bolts or permanent fixtures somewhere, use some point on the fixtures as your work origin, instead of an origin on the part (need to have fixture in CAM), maybe because you have stock material with changeing shape and don’t want to touch off every time… Then it’s really nice to have. 
Or if you’d like to use autosquaring:
But other than that: Nah… As the others said 
EDIT: I see, my thread linking skills are lacking… just look at the threads if you’re interested ^^