If you’re referring to the arcade panel, yes, there are some different layouts. But it’s all about maximizing compatibility with as many games as possible. I’m going with 7 buttons for players 1 and 2 as this arrangement covers the control layouts for most Capcom and NeoGeo games, plus works well with Mortal Combat and many other 2-player games.
Very few arcade games use more than 4 buttons for players 3 and 4, so it’s a bit of a waste to add more. I’ll also have USB connections for physical controllers if needed.
The center controls are mirrored to Player 1 with buttons 1-3, but the joystick is set to 4-way instead of 8-way for compatibility on older games (e.g. PacMan) that don’t handle 8-way joysticks gracefully.
There’s also a trackball for Golden Tee or bowling games, and a spinner…though I don’t really have any games lined up for that yet. I don’t know if my way is the best way, but after some fairly extensive research, this is what made the most sense to me.