This is a common question before folks start a build.
Here’s a thread where it was addressed:
Most think you’re sacrificing a little potential performance but that it should work. I’ve considered it because it would let me have the flexibility to temporarily set up a full sheet and transfer the gantry for special projects. However, it’s definitely not the easiest path to a working machine because of the inability to cut its own struts in a single operation.
Good luck!